王晓霞

【来源:兰州大学公共卫生学院 | 发布日期:2014-07-18 】     【选择字号:

王晓霞 博士、兰州大学公共卫生学院副教授、公共卫生专业学位硕士生导师,兰州大学“萃英计划”引进人才。主讲课程:《卫生微生物学》、《医学微生物学》。主要研究方向:以HIV及重大人兽共患病毒病为研究对象,从细胞和活体水平上研究病原与宿主间相互作用的分子机制、表观遗传学调控方式和免疫应答规律。

主要学习工作简历:

2014/7 - 至今,兰州大学,公共卫生学院,副教授

2009/9 - 2014/2University of Manitoba(加拿大曼尼托巴大学),医学微生物学,博士

2006/9 - 2009/6,西北农林科技大学,预防兽医学,硕士

2002/9 - 2006/7,西北农林科技大学,动物医学,学士

主持或参加科研项目及人才计划项目情况:

1、国家自然基金青年基金项目,APOBEC3对潜伏HIV-1的激活作用及其与DNA甲基化修饰的关系,815017342016/01-2018/12,主持。

2、国家自然科学基金青年基金项目,81803308,镍暴露与DNA甲基化对COPD发病影响及机制的巢式病例对照研究,2019/01-2021/12,参与

3、中央高校基本科研业务费专项资金,兰州大学自由探索面上项目:基于APOBEC3分子的清除HIV-1潜伏库的策略研究,lzujbky-2015-2602015/07-2016/12,主持

4、中央高校基本科研业务费专项资金,兰州大学自由探索面上项目: APOBEC3A在激活潜伏HIV-1中的作用及其机制研究,lzujbky-2015-1852015/01-2016/06,主持。

5、兰州大学 “萃英人才”队伍建设经费,4万,2014/7-2017/6,主持。

发表文章列表

Xiaoxia Wang, Zhujun Ao, Kallesh Danappa Jayappa, Bei Shi, Gary Kobinger and Xiaojian Yao*. R88-APOBEC3Gm inhibits the replication of both drug-resistant strains of HIV-1 and viruses produced from latently infected cells. Molecular Therapy-Nucleic Acids. 2014, 3, e151.

Xiaoxia Wang, Zhujun Ao, Liyu Chen, Gary Kobinger, Jinyu Peng and Xiaojian Yao*. The cellular antiviral protein APOBEC3G interacts with HIV-1 reverse transcriptase and inhibits its function during viral replication. J Virol. 2012, Apr; 86(7):3777-86.

Xiangxiang Qin, Lei Chen, Xiaoning Liu, Shuilin Zheng and Xiaoxia Wang*. Factors affecting body mass index in overweight/obese university students, Gansu, China: a cross sectional study. Southeast Asian J Trop Med Public Health, 2018, 49(4):685-695.(Corresponding author)

覃向向, 王晓霞, 陈磊, 郑水林. 饮食因素对肠道菌群影响的研究进展. 中国微生态学杂志, 2017, 29(12):1480-1482+1489(通讯作者)

魏小乐,王晓霞,贾怀杰,景志忠,王永祥,谭继英. 载脂蛋白B mRNA编辑酶催化亚基3A的表达及其DNA去甲基化功能鉴定. 兰州大学学报(医学版),2018, 44(03):8-15.(共同通讯作者)

Xiaoling Gao, Cong Wu, Xiaoxia Wang, Hui Xu, Yu Wu, Yonghong Li, Yanjuan Jia, Chaojun Wei, Wenhua He, Yongxiang Wang, Benzhong Zhang*. The DosR antigen Rv1737c from Mycobacterium tuberculosis confers inflammation regulation in tuberculosis infection. Scandinavian Journal of Immunology, 2018, 89(1) Oct 29:e12729. doi: 10.1111/sji.12729

Wenyu Cheng, Huaijie Jia, Xiaoxia Wang, Xiaobing He, Qiwang Jin, Jinxin Cao, Zhizhong Jing*. Ectromelia virus upregulates the expression of heat shock protein 70 to promote viral replication. International Journal of Molecular Medicine, 2018, 42(2): 1044-1053.

Huaijie Jia, Leilei Zhan, Xiaoxia Wang, Xiaobing He, Guohua Chen, Yu Zhang, Yuan Feng, Yaxun Wei, Yi Zhang, Zhizhong Jing*. Transcriptome analysis of sheep oral mucosa response to Orf virus infection. PLOS ONE, 2017, Oct. 26:1-14.

Wenyu Cheng, Huaijie Jia, Xiaobing He, Guohua Chen, Yuan Feng, Chunyan Wang, Xiaoxia Wang, Zhizhong Jing*. Comparison of host gene expression profiles in spleen tissues of genetically susceptible and resistant mice during ECTV infection. BioMed Research International, 2017, doi:10.1155/2017/6456180.

Zhujun Ao, Jing Huang, Xiaoli Tan, Xiaoxia Wang, Tian Tian, Xu Zhang, Qingjian Ouyang, Xiaojian Yao*. Characterization of the single cycle replication of HIV-1 expressing Gaussia luciferase in human PBMCs, macrophages, and in CD4+ T cell-grafted nude mouse. Journal of Virological Methods. 2016, 228:95-102.

Danappa Jayappa Kallesh, Zhujun Ao, Xiaoxia Wang, Andrew J Mouland, Sudhanshu Shekhar, Xi Yang, Xiaojian Yao*. Human Immunodeficiency Virus Type 1 employs the cellular dynein light chain 1 protein for reverse transcription through interaction with its integrase protein. J Virol. 2015, Apr; 89(7): 3497-511.

Jinyu Peng, Zhujun Ao, Chris  Matthews, Xiaoxia Wang, Sue  Ramdahin, Xi Chen, Junhua Li, Liyu  Chen, Jianmei He, Blake  Ball, Keith Fowke, Frank  Plummer, Joanne  Embree, Xiaojian Yao*. A naturally occurring Vif mutant (I107T) attenuates anti-APOBEC3G activity and HIV-1 replication. Journal of Molecular Biology, 2013 Aug 23; 425(16):2840-52.

Tao Zhou, Huaijie Jia, Guohua Chen, Xiaobing He, Yongxiang Fang, Xiaoxia Wang, Qisai Guan, Shuang Zeng, Qing Cui and Zhizhong Jing*. Phylogenetic analysis of Chinese sheeppox and goatpox virus isolates. Virol J. 2012 Jan 20, 9:25.

Zhujun Ao, Kallesh Danappa Jayappa, Binchen Wang, Yingfeng Zheng, Xiaoxia Wang, Jinyu Peng, and Xiaojian Yao*. Contribution of host nucleoporin 62 in HIV-1 integrase chromatin association and viral DNA integration. J Biol Chem. 2012, Mar 23; 287(13):10544-55.

Zhujun Ao, Xiaoxia Wang, Alexander Bello, Kallesh Danappa Jayappa, Zhe Yu, Keith Fowke, Xinying He, Xi Chen, Junhua Li, Gary Kobinger, and Xiaojian Yao*. Characterization of anti-HIV activity mediated by R88-Apobec3G mutant fusion proteins in CD4+ T cells, PBMCs and macrophages. Human Gene Therapy, 2011 Oct; 22(10):1225-37.

参编教材

参编《卫生微生物学》(第六版)、《卫生微生物学实习指导与习题集》(第四版)、《医学微生物学教学案例与学习指导》、《天然分子免疫学》

获奖情况

20155月公共卫生学院第二届学院青年教师讲课比赛三等奖

20174月公共卫生学院第三届青年教师讲课比赛三等奖

20175月兰州大学医学院第四届青年教师教学基本功比赛三等奖

20173月兰州大学“工会积极分子”

联系方式:wangxiaoxia@lzu.edu.cn