常旭红，男，博士，卫生毒理学系副教授，硕士研究生导师，医学部医学科学技术处副处长。

2011.3—2014.6  东南大学公共卫生学院，流行病与卫生统计学，博士

2006.9—2009.6  兰州大学公共卫生学院，卫生毒理学，硕士

2001.9—2006.6  兰州大学公共卫生学院，预防医学，学士

2022.5—至今    兰州大学医学部医学科学技术处，副处长

2018.7—至今    兰州大学公共卫生学院，副教授

2016.9—2019.7  中共兰州大学公卫院营养所与毒理所教工党支部，书记

2016.9—2021.6  兰州大学公共卫生学院2016级预防医学本科生，班主任

2016.3—2016.8  中共兰州大学公卫院营养所与毒理所教工党支部，副书记

2016.3—2019.4  兰州大学公共卫生学院工会，文体委员

2015.9—2019.7  兰州大学公共卫生学院卫生毒理学研究所，秘书

2014.7—2018.6  兰州大学公共卫生学院，讲师

2009.7—2011.2  蚌埠医学院预防医学系卫生学教研室，助教

本科生：预防医学、预防医学实验、卫生毒理学
研究生：现代毒理学进展
教学研究：主持兰州大学《预防医学》课程思政示范课程、《预防医学》课程思政案例库建设、《卫生毒理学》教学团队建设、医学本科教育教学水平提升等项目，发表教育教学改革论文10余篇。

研究方向：纳米毒理，分子与细胞毒理，肝肺纤维化分子机制，呼吸疾病前瞻性研究

主持或参与科研项目：

1.兰州市科技计划项目，新型circRNA调控miR-181在纳米氧化镍致肺纤维化中的分子机制，2023/9-2025/9，主持

2.甘肃省卫健委中医药科研课题，甘肃省三级公立中医医院绩效考核中医特色指标研究，2023/1-2024/12，主持

3.兰州市城关区人才创新创业项目，肠道菌群-肠-肝轴在纳米NiO致肝纤维化中的作用机制，2022/12-2025/11，主持

4.甘肃省科技计划项目-重点研发计划，lncRNA调控相关基因DNA甲基化在纳米氧化镍诱导肺纤维化中的表观遗传学机制研究，2021/10-2023/9，参与

5.兰州大学中央高校基本科研业务费专项资金自由探索项目，circRNA调控Wnt/β-catenin信号通路在纳米NiO致肺纤维化中的分子机制，2019/01-2020/12，主持

6.国家自然科学基金，lncRNA调控TGF-β1在纳米NiO致肺纤维化中的作用及分子机制，2019/1-2022/12，参与

7.国家自然科学基金青年项目，TGF-β1介导的信号通路诱发EMT在纳米NiO致肺纤维化中的作用，2017/01-2019/12，主持

8.国家自然科学基金，Loc101928316介导Wnt通路在致癌物MNNG诱发胃癌中的作用机制研究，2019/1-2021/12，参与

9.兰州市人才创新创业项目，2017-RC-79，天然植物化学物联合治疗酒精性肝损伤的开发研究，2018/01-2019/12，参与

10.兰州市科技计划项目，兰州市农村介水传染病预防控制技术研究与推广，2016/01-2018/12，主持

发表主要论文：

1.Jinfa Zheng, Jinyu Wang, Kun Li, Xin Qin, Sheng Li, Xuhong Chang, Yingbiao Sun. LncRNA AP000487.1 regulates PRKCB DNA methylation- mediated TLR4/MyD88/NF-κB pathway in Nano NiO-induced collagen formation in BEAS-2B cells. Environmental Toxicology. 2023, doi.org/10.1002/tox.23918.

2.Rui Xu, Jinpeng Hu, Lili Chen, Junfang Miao, Qiang Wang, Jijun Hu, Xuhong Chang, Jinlin Zhang. Food Sources May Affect the Symptom Rates of COVID-19, an Epidemiological Analysis Based on the Public Data in Gansu Province, China, During the Summer Epidemic Cycle in 2022. Disaster Medicine and Public Health Preparedness. 2023, 17(e393): 1-5.

3.Honglong Zhang, Jun Yan, Ye Xie, Xuhong Chang, Junliang Li, Chenghui Ren, Jun Zhu, Longfei Ren, Kuo Qi, Zhongtian Bai, Xun Li. Dual role of cadmium in rat liver: Inducing liver injury and inhibiting the progression of early liver cance. Toxicology Letters. 2022, 355, 62-81.

4.Yang Mengmeng, Chang Xuhong, Gao Qing, Gong Xuefeng, Zheng Jinfa, Liu Han, Li Kun, Zhan Haibing, Wang Xiaoxia, Li Sheng, Sun Xingchang, Feng Sanwei, Sun Yingbiao. LncRNA MEG3 ameliorates NiO nanoparticles-induced pulmonary inflammatory damage via suppressing the p38 mitogen activated protein kinases pathway. Environmental Toxicology. 2022, 37(5): 1058-1070.

5.Li Kun, Zheng Jinfa, Liu Han, Gao Qing, Yang Mengmeng, Tang Jiarong, Wang Hui, Li Sheng, Sun Yingbiao, Chang Xuhong. Whole-transcriptome sequencing revealed differentially expressed mRNAs and non-coding RNAs played crucial roles in NiONPs-induced liver fibrosis. Ecotoxicology and Environmental Safety. 2022, 248: 114308.

6.Gao Qing, Chang Xuhong, Yang Mengmeng, Zheng Jinfa, Gong Xuefeng, Liu Han, Li Kun, Wang Xiaoxia, Zhan Haibing, Li Sheng, Feng Sanwei, Sun Xingchang, Sun Yingbiao. LncRNA MEG3 restrained pulmonary fibrosis induced by NiO NPs via regulating hedgehog signaling pathway-mediated autophagy. Environmental Toxicology. 2022, 37(1): 79-91.

7.Zheng Jinfa, Wang Jinyu, Qin Xin, Li Kun, Gao Qing, Yang Mengmeng, Liu Han, Li Sheng, Chang Xuhong, Sun Yingbiao. LncRNA HOTAIRM1 involved in Nano NiO-induced pulmonary fibrosis via regulating PRKCB DNA methylation-mediated JNK/c-Jun pathway. Toxicological Sciences. 2022, 190(1): 64-78.

8.Jingjing Liu, Xin Zhang, Xiaojuan Ta, Miaomiao Luo, Xuhong Chang, Hui Wang. Fecal microbiome transplantation attenuates manganese-induced neurotoxicity through regulation of the apelin signaling pathway by inhibition of autophagy in mouse brain. Ecotoxicology and Environmental Safety. 2022, 242: 113925.

9.Dongsheng Zhu, Jinyu Wang, Yurui Zhao, Lu Yang, Jinxia Gao, Xuhong Chang, Sheng Li, Yanni Zheng. The Status of Occupational Stress and Its Influence on the Health of Medical Staff in Lanzhou, China. 2022, 19(17): 10808.

10.Zhan Hanbing, Sun Xingchang, Wang Xiaoxia, Gao Qing, Yang Mengmeng, Liu Han, Zheng Jinfa, Gong Xuefeng, Feng Sanwei, Chang Xuhong, Sun Yingbiao. LncRNA MEG3 Involved in NiO NPs-induced pulmonary fibrosis via regulating TGF-β1-mediated PI3K/AKT pathway. Toxicological Sciences. 2021, 182(1): 120-131.

11.Zhang Qiong, Chang Xuhong, Wang Xiaoxia, Zhan Haibing, Gao Qing, Yang Mengmeng, Liu Han, Li Sheng, Sun Yingbiao. A metabolomic-based study on disturbance of bile acids metabolism induced by intratracheal instillation of nickel oxide nanoparticles in rats. Toxicology Research. 2021, 10(3): 579-591.

12.Zhan Hanbing, Chang Xuhong, Wang Xiaoxia, Yang Mengmeng, Gao Qing, Liu Han, Li Chengyu, Li Sheng, Sun Yingbiao. LncRNA MEG3 mediates nickel oxide nanoparticles-induced pulmonary fibrosis via suppressing TGF-β1 expression and epithelial-mesenchymal transition process. Environmental Toxicology. 2021, 36(6): 1099-1110.

13.Xiaoxia Wang, Xuhong Chang, Haibing Zhan, Chengyun Li, Qiong Zhang, Sheng Li, Yingbiao Sun. Curcumin combined with Baicalin attenuated ethanol-induced hepatitis by suppressing p38 MAPK and TSC1/eIF-2α/ATF4 pathways in rats. Food Bioscience. 2021, 40:100851.

14.Xiaoxia Wang, Xuhong Chang, Haibing Zhan, Qiong Zhang, Chengyun Li, Qing Gao, Mengmeng Yang, Zhen Luo, Sheng Li, Yingbiao Sun. Curcumin and Baicalin ameliorate ethanol-induced liver oxidative damage via the Nrf2/HO-1 pathway. J Food Biochem, 2020, 44(10): e13425.

15.Chang Xuhong, Tian Minmin, Zhang Qiong, Gao Jinxia, Li Sheng, Sun Yingbiao. Nano nickel oxide promotes epithelial-mesenchymal transition through transforming growth factor β1/smads signaling pathway in A549 cells. Environmental Toxicology. 2020, 35(12): 1308-1317.

16.Qiong Zhang, Xuhong Chang, Haibing Wang, Yunlan Liu, Xiaoxia Wang, Minmin Wu, Haibing Zhan, Sheng Li, Yingbiao Sun. TGF-β1 mediated Smad signaling pathway and EMT in hepatic fibrosis induced by Nano NiO in vivo and in vitro. Environmental Toxicology. 2020(4), 35: 419-429.

17.Tian Minmin, Chang Xuhong, Zhang Qiong, Li Chengyun, Li Sheng, Sun Yingbiao. TGF-β1 mediated MAPK signaling pathway promotes collagen formation induced by Nano NiO in A549 cells. Environmental Toxicology. 2019, 34(6): 719-727.

18.Xuhong Chang, Hongjun Zhao, Jinxia Gao, Lijuan chen, An Zhu, Cheng Wang, Shu Yu, Xiaolan Ren, Pengfei Ge, Yingbiao Sun. Pulmonary toxicity of exposure to nano nickel oxide. Micro & Nano Letters. 2018, 13(6): 733-738.

19.Minmin Tian, Fangfang Liu, Han Liu, Qiong Zhang, Lei Li, Xiangbo Hou, Jianxin Zhao, Sheng Li, Xuhong Chang, Yingbiao Sun. GSPE attenuates Cis-induced oxidative stress and testosterone synthase inhibition in rat testes. Syst Biol Repro Med. 2018, 290(3): 246-259.

20.Shu Yu, Fangfang Liu, Chen Wang, Jinyi Zhang, An Zhu, Lingyue Zou, Aijie Han, Jin Li, Xuhong Chang, Yingbiao Sun. Role of oxidative stress in liver toxicity induced by nickel oxide nanoparticles in rats. Mol Med Rep. 2018, 17(1): 3133-3139.

21.Chang Xuhong, Liu Fangfang, Tian Minmin, Hongjun Zhao, Aijie Han, Yingbiao Sun. Nickel oxide nanoparticles induce hepatocyte apoptosis via activating endoplasmic reticulum stress pathways in rats. Environmental Toxicology. 2017, 32(12): 2492-2499.

22.Xuhong Chang, An Zhu, Fangfang Liu, Lingyue Zou, Li Su, Sheng Li, Yingbiao Sun. Role of NF-κB Activation and Th1/Th2 Imbalance in Pulmonary Toxicity Induced by Nano NiO. Environmental Toxicology. 2017, 32(4): 1354-1362.

23.Xuhong Chang, An Zhu, Fangfang Liu, Lingyue Zou, Li Su, Shaokun Liu, Honghua Zhou, Yanyan Sun, Aijie Han, Yifan Sun, Sheng Li, Jin Li, Yingbiao Sun. Nickel oxide nanoparticles induced pulmonary fibrosis via TGF-beta1 activation in rats. Hum Exp Toxicol. 2017, 36(8): 802-812.

24.Fangfang Liu, Xuhong Chang, Minmin Tian, An Zhu, Lingyue Zou, Aijie Han, Li Su, Sheng Li, Yingbiao Sun. Nano NiO induced liver toxicity via activating the NF-κB signaling pathway in rats. Toxicol Res. 2017, 6(2): 242-250.

25.An Zhu, Xuhong Chang, Yingbiao Sun, Lingyue Zou, Li Su, Yifan Sun, Sheng Li, Shaokun Liu, Yanyan Sun, Honghua Zhou, Jin Li. Role of oxidative stress and inflammatory response in subchronic pulmonary toxicity induced by nano nickel oxide in rats. J Nanosci Nanotechno. 2017, 17(3): 1753-1761.

参编教材：

1.《心血管毒理学》，北京大学医学出版社，2018年01月，参编

2.《生活中的毒理》，人民卫生出版社，2020年09月，参编

3.《预防医学》，人民卫生出版社，2020年05月，参编

中国环境诱变剂学会青年委员会委员，中国毒理学会会员，《兰州大学学报（医学版）》编辑委员会青年编辑委员，教育部学位中心研究生论文评审专家，兰州大学校友总会公共卫生学院分会理事；Environmental Toxicology、Toxicology Research、Human and Experimental Toxicology等杂志审稿人。

1.2023年“石化区重大环境与居民健康问题研究及健康促进模式推广”，甘肃省科技进步奖，二等奖，5/9

2.2022年“基于生物监测的多环芳羟和重金属暴露水平、健康风险和防控策略”，甘肃省科技进步奖，二等奖，5/9

3.2022年“天然植物化学物联合治疗酒精性肝损伤的开发研究”，甘肃医学科技奖，三等奖，2/5

4.2021年“兰州市重点环境化学物质人群暴露调查研究及防控应用推广”，甘肃医学科技奖，二等奖，5/7

5.2021年“突发公共卫生事件案例仿真教学”在《预防医学》课程中的应用，兰州大学教学成果奖，二等奖，3/7

6.2020年“兰州市农村介水传染病预防控制技术研究与推广”，甘肃医学科技奖，三等奖，1/5

7.2019年“第二届全国大学生公共卫生综合知识与技能大赛”三等奖指导教师

8.2019年兰州大学公共卫生学院第四届青年教师教学竞赛，一等奖

9.2019年兰州大学公共卫生学院第四届青年教师教学竞赛，最佳教案奖

10.2018年“基于纳米氧化镍致大鼠肝脏氧化损伤的实践创新能力提升”，兰州大学教学成果奖，二等奖，2/2

11.2018年兰州大学公共卫生学院“课程思政”示范讲课比赛，三等奖

12.2018年“肽基脯氨酸顺反异构酶”的遗传变异与武威地区胃癌环境危险因素的交互作用，甘肃医学科技奖，三等奖，4/5

13.2018年兰州大学毕业论文（设计）优秀指导教师

14.2018年中共兰州大学基层组织建设年，优秀党支部书记

15.2017年兰州大学公共卫生学院，优秀党员

16.2017年兰州大学医学院第四届青年教师教学基本功比赛，二等奖

17.2017年兰州大学公共卫生学院第三届青年教师讲课比赛，一等奖