2007.09-2011.06，兰州大学，生命科学学院，生物技术专业，理学学士

2011.09-2018.06，兰州大学，生命科学学院，动物学专业，理学博士

2018.07至今     兰州大学公共卫生学院，讲师

研究方向：

1. 重金属胁迫诱导神经毒性的分子机制；

2. 重金属胁迫诱导线粒体自噬的分子机制。

主持或参与科研项目：

1. 甘肃省自然科学基金，甘肃省科技计划项目（创新基地和人才计划）（20JR5RA248），纳米硒对镍致睾酮合成障碍的拮抗作用及其分子机制，2020-11至2022-10，在研，参与。

2. 兰州大学中央高校基本科研业务费专项资金自由探索项目（自然科学类）新来校教师科研启动费项目（lzujbky-2019-7），线粒体铁硫簇生物合成在铅致神经毒性中的作用，2019-01至2020-12，已结题，主持。

3. 兰州大学中央高校基本科研业务费专项资金自由探索项目（自然科学类）优秀研究生创新项目（lzujbky-2015-227），ATM对铅诱导的线粒体自噬的调控机制探究，2015-01至2016-06，已结题，主持。

4. 国家自然科学基金青年科学基金项目（31300941），ROS和ATM蛋白在亚精胺致线粒体自噬过程中的调控作用，2014-01至2016-12，已结题，参加。

发表主要论文或专著:

1. Caixia Wang¹, Zhangyu Gu¹, Xueyan Gu¹, Xinyue Tan, Shuang Wang, Rui Zhang, Ruifen Li, Mingkun Sun, Chunyan Gui, Sheng Li, Yixing Ye, Jianhua Ma, Li Su*, Changhao Liang*. Nano-selenium attenuates mitochondrial-associated apoptosis via the PI3K/AKT pathway in nickel-induced hepatotoxicity in vivo and in vitro. Environmental Toxicology, 2022, 101-119.

2. Yongmei Qi¹, Lin Ma¹, Sajid Naeem, Xueyan Gu, Xijuan Chao, Cong Yuan, Dejun Huang. Pb induced mitochondrial fission of fibroblast cells via ATM activation, Journal of Hazardous Materials,2021, 416: 126177.

3. Caixia Wang¹, Li Su¹, Qiuling Mu, Xueyan Gu, Xuejun Guo*, Xuxia Wang*. Cost-effectiveness analysis of China domestic 13-valent pneumococcal conjugate vaccine for children under 5 years of age in mainland China. Human Vaccines & Immunotherapeutics, 2021, 12:1-8.

4. Qiannan E, Caixia Wang, Xueyan Gu, Xiaoqin Gan, Xiaotian Zhang, Shuang Wang, Jianhua Ma, Li Zhang, Rui Zhang, Li Su*. Competitive endogenous RNA (ceRNA) regulation network of lncRNA-miRNA-mRNA during the process of the nickel-induced steroidogenesis disturbance in rat Leydig cells. Toxicol in Vitro, 2020, 63:104721.

5. Xueyan Gu, Yongmei Qi*, Zengxiu Feng, Lin Ma, Ke Gao, Yingmei Zhang*. Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway. Toxicol Lett, 2018, 291: 92-100.

6. Yuanzhen Xu¹, Xueyan Gu¹, Shoujiao Peng, Jianguo Fang, Yingmei Zhang, Dejun Huang, Jianjun Chen*, Kun Gao*. Design, synthesis and biological evaluation of novel sesquiterpene mustards as potential anticancer agents. Eur J Med Chem, 2015, 94: 284-297.

7. Tingting Ge, Jianyuan Han, Yongmei Qi, Xueyan Gu, Lin Ma, Chen Zhang, Sajid Naeem, Dejun Huang*. The toxic effects of chlorophenols and associated mechanisms in fish, Aquat Toxicol, 2017, 184: 78-93.

8. Yongmei Qi¹, Qian Qiu¹, Xueyan Gu, Yihong Tian, Yingmei Zhang*. ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts, Sci Rep-UK, 2016, 6: 24700.

9. Weiwei Li, Xueyan Gu, Xiaoning Zhang, Jinxin Kong, Nan Ding, Yongmei Qi, Yingmei Zhang, Dejun Huang*. Cadmium delays non-homologous end joining (NHEJ) repair via inhibition of DNA-PKcs phosphorylation and downregulation of XRCC4 and Ligase IV, Mutat Res-Fund Mol M, 2015, 779: 112-123.

10. Zhidan Niu, Wenya Zhang*, Xueyan Gu, Xiaoning Zhang, Yongmei Qi, Yingmei Zhang*. Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells, Environ Toxicol Phar, 2016, 45: 212-221.

11. Xue Wei, Yongmei Qi, Xiaoning Zhang, Xueyan Gu, Hui Cai, Jing Yang, Yingmei Zhang*. ROS act as a upstream signal to mediate cadmium-induced mitophagy in mouse brain, NeuroToxicology, 2015, 46: 19-24.

12. Yuanzhen Xu, Jianjun Chen, Ya Li, Shoujiao Peng, Xueyan Gu, Meng Sun, Kun Gao*, Jianguo Fang*. Synthesis and biological studies of the thiols-triggered anticancer prodrug for a more effective cancer therapy, Org Biomol Chem, 2015, 13: 2634-2639.

13. Xue Wei, Yongmei Qi, Xiaoning Zhang, Qian Qiu, Xueyan Gu, Chen Tao, Dejun Huang, Yingmei Zhang*. Cadmium induces mitophagy through ROS-mediated PINK1/Parkin pathway, Toxicol Mech Method, 2014, 24: 504-511.

2021年兰州大学公共卫生学院优秀共产党员；

2020年兰州大学公共卫生学院“课程思政”示范课程讲课比赛三等奖；

2019年兰州大学公共卫生学院第四届青年教师教学竞赛三等奖；

2018年兰州大学优秀毕业生；

2016年博士研究生国家奖学金。